Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,086 – 5,100 of 60,541 results

5,086

Apexbio Technology LLC GSK 2837808A 1445879-21-9 25mg

GSK 2837808A (CAS 1445879-21-9) is a small-molecule inhibitor that selectively targets lactate dehydrogenase A (LDHA) exhibiting potent inhibitory activity with IC50 values of 1 9 nM for LDHA and 14 nM for LDHB In cellular studies GSK 2837808A at 10 M reduced glucose consumption in Snu398 hepatocellular carcinoma cells but not in HepG2 cells indicating cell line-specific metabolic effects Pharmacokinetic analysis in rodents demonstrated rapid clearance following intravenous administration and minimal systemic exposure after oral dosing GSK 2837808A serves as a valuable tool for investigating LDHA function and metabolic regulation in cancer research

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5,087

Cayman Chemical EB 47 (hydrochloride), Purity: ≥98%, CAS: 1190332-25-2, 5 mg

A PARP1 and TNKS2 inhibitor (IC50 = 45 nM for both); an inhibitor of TNKS1 and PARP10 (IC50s = 410 and 1,179 nM, respectively); reduces infarct volume in a rat model of MCAO occlusion-induced ischemia-reperfusion injury at 10 mg/kg per hour

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5,088

Cayman Chemical Elinogrel, Purity: ≥98%, CAS: 936500-94-6, 1 mg

A reversible antagonist of P2Y12 (Ki = 23 nM); inhibits platelet aggregation in an hPRP assay (IC50 = 2.81 nM); inhibits thrombosis in a mouse model of vascular injury induced by FeCl3 at 60 mg/kg

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5,089

TARGETMOL CHEMICALS INC DEBIO-0123 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Debio-0123 (WEE1-IN-5) is a potent orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. Debio-0123 inhibits phospho-CDC2 which translated into an increase in DNA damage and premature entry into mitosis. Debio-0123 increases the antitumoral activity of Carboplatin in vivo whereas neither agent was active alone [1]. purity: 99%

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5,090

Medchemexpress LLC Eleutheroside C | 15486-24-5 | 1 MG

Eleutheroside C (Ethyl α-D-galactoside) is a glycoside isolated from the bulbs of *Polianthes tuberosa*. It has a molecular weight of 208.21 and a chemical formula of C8H16O6. This white to off-white solid is classified as a saccharide and originates from plants in the Araliaceae family, specifically *Acanthopanax senticosus (Rupr. et Maxim.) Harms*.

Purity: 99.90%
For research use only
Shipped at room temperature in continental US
Store at 4°C, protected from light
Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light

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5,091

Cayman Chemical diABZI STING Agonist 1 (hydrochloride), Purity: ≥98%, CAS: 2138299-34-8, 5 mg

An activator of the STING pathway; induces secretion of IFN-β in human PBMCs (EC50 = 130 nM); increases serum levels of Ifn-β, Il-6, Tnf, and Cxcl1 in wild-type, but not Sting-/-, mice at 2.5 mg/kg; inhibits the cytopathic effect of HCoV-229E in infected MRC-5 cells (EC50 = 3 nM); decreases the levels of SARS-CoV-2 RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay; decreases tumor volume and increases survival in a CT26 murine colorectal cancer model at 3 mg/kg; this compound is expected to exist in one or both tautomeric forms

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5,092

Medchemexpress LLC Etimizol | 64-99-3 | 99.9% | 210.23 | 50 MG

Etimizol (Ethymisole), a nootropic agent, effectively relieves amnesia, especially when linked to hypoxic components like hypobaric hypoxia, actinomycin D, or mechanical brain injury. It works by decreasing the K-+ permeability of neuron membranes during action potential. This product is intended for research use only.

Effectively relieves amnesia
Decreases K-+ permeability of neuron membranes
Suitable for research applications
Acts as a potassium channel inhibitor

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5,093

Cayman Chemical 3,5-Dinitrocatechol, Purity: ≥98%, CAS: 7659-29-2, 5 mg

A potent COMT inhibitor (IC50 = 12 nM); selective for COMT over tyrosine hydroxylase, dopamine β-hydroxylase, dopamine decarboxylase, MAO-A, and MAO-B (IC50s = >14 μM for all); reduces 3-OMD levels in rat serum when administered in combination with L-DOPA and carbidopa compared with control animals receiving only L-DOPA and carbidopa at 30 mg/kg; chronic administration induces COMT-dependent thermal hyperalgesia and increases preference for dark in a light/dark preference test in rats at 15 mg/kg per day for seven days

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5,094

Cayman Chemical Arachidonoyl Chloride, Purity: ≥95%, CAS: 57303-04-5, 5 mg

A derivative of arachidonic acid; has been used as an intermediate in the synthesis of arachidonic acid derivatives

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5,095

Medchemexpress LLC Perfluorobutylsulfonyl fluoride | 375-72-4 | 99.9% | 302.09 | 50 G

Perfluorobutylsulfonyl fluoride is a biological molecule. It is intended for research use only and not for sale to patients. This product is a liquid with a density of 1.774±0.06 g/cm3 and appears colorless to light yellow.

Shipping at room temperature in continental US; may vary elsewhere
Storage of pure form at -20°C for 3 years, 4°C for 2 years
Storage in solvent at -80°C for 6 months, -20°C for 1 month

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5,096

Cayman Chemical ICAAc, Purity: ≥98%, 25 mg

A solvatochromic fluorescent pH probe; ex/em = 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively; abs/em = 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous buffer, with fluorescence intensity increasing as pH decreases; can be used for live cell applications

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5,097

AdipoGen Enniatin A1 (1 mg)

Chemical. CAS: 4530-21-6. Formula: C35H61N3O9. MW: 667.9. Isolated from fungus Fusarium sp. Cyclohexadepsipeptide mycotoxin. One of four major analogs in the enniatin complex. Commonly found food contaminant in cereals and their products. Ionophore antibiotic. Incorporation into the cell membrane forms dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. Anticancer compound. Triggers apoptosis in several cancer cell lines. Induced apoptosis in cancer cells (H4IIE rat hepatoma cells), decreasing the activation of the cell proliferation kinase, ERK (p44/p42) and inhibiting TNF-alpha-induced NF-kappaB activation. Moderate inhibitor of ACAT (acylcoenzyme A:cholesterolacyl transferase). Shown to have a variety of other biological activities such as antifungal, anthelmintic, insecticidal, immunomodulatory and phytotoxic activity.

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5,098

Medchemexpress LLC CD40L/CD154/TRAP Hu 100ug

Recombinant human CD40L soluble form (M113-L261) produced in HEK293 cells with N-terminal hFc and Flag tags, supplied as a lyophilized powder. The product is high purity and low endotoxin, formulated with trehalose to support stability and performance in functional binding and cell-based assays.

High purity (>95%) for reliable biochemical assays.
Low endotoxin level (<1 EU/μg) to minimize cellular activation artifacts.
N-terminal hFc and Flag tags facilitate detection and capture.
Lyophilized formulation with trehalose for enhanced stability.
Validated in ELISA, LSPR, and B-cell proliferation assays.
Stable when stored at -20°C and suitable for long-term storage with carrier protein.

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5,099

Cayman Chemical GLX-351322, Purity: ≥98%, CAS: 835598-94-2, 10 mg

A NOX4 inhibitor (IC50 = 5 µM); selective for NOX4 over NOX2 (IC50 = 40 µM); reduces glucose-induced production of ROS and cytotoxicity in isolated human pancreatic islets at 10 µM; decreases blood glucose levels in an intravenous glucose tolerance test in mice fed a high-fat diet at an estimated 3.8 mg/kg per day

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5,100

TARGETMOL CHEMICALS INC AR-A014418 50MG

Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AR-A014418 (GSK 3(beta) inhibitor VIII) is an ATP-competitive and selective GSK3(beta) inhibitor. purity: 99%

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Bioactive Small Molecules

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Medchemexpress LLC Eleutheroside C | 15486-24-5 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Etimizol | 64-99-3 | 99.9% | 210.23 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Perfluorobutylsulfonyl fluoride | 375-72-4 | 99.9% | 302.09 | 50 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CD40L/CD154/TRAP Hu 100ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Eleutheroside C | 15486-24-5 | 1 MG

Medchemexpress LLC Etimizol | 64-99-3 | 99.9% | 210.23 | 50 MG

Medchemexpress LLC Perfluorobutylsulfonyl fluoride | 375-72-4 | 99.9% | 302.09 | 50 G

Medchemexpress LLC CD40L/CD154/TRAP Hu 100ug